This is how you can get Zine + lighty running under Gentoo in 5 minutes

1. Install the required python packages for Zine

(root) # cat /etc/portage/package.keywords

(root) # emerge -av sqlalchemy jinja2 werkzeug simplejson html5lib pytz Babel lxml flup

2. Download and Install Zine

(download) $ wget
(download) $ tar zxvf Zine-0.1.2.tar.gz
(download) $ cd Zine-0.1.2

# Use --prefix to install zine to a different location than default (/usr)
(Zine-0.1.2) $ ./configure --prefix=/srv/usr && make install

# Create a working directory for your Zine fastcgi and configuration files
(Zine-0.1.2) $ mkdir -p /var/www/zine
(Zine-0.1.2) $ cp servers/zine.fcgi /var/www/zine

# Edit zine.fcgi to update INSTANCE_FOLDER and ZINE_LIB
(Zine-0.1.2) $ nano /var/www/zine/servers/zine.fcgi
INSTANCE_FOLDER = '/var/www/zine';  
ZINE_LIB = '/srv/usr/lib/zine';
(Zine-0.1.2) $ chown lighttpd /var/www/zine
(Zine-0.1.2) $ chmod 755 /var/www/zine/zine.fcgi

3. Update lighttpd configuration

# Edit /etc/lighttpd/mod_fastcgi.conf for global fcgi handler setup or
# add fastcgi.server to your VHOST config
(root) # nano /etc/lighttpd/mod_fastcgi.conf
fastcgi.server = ('' =>  
'bin-path' => '/var/www/zine/zine.fcgi',  
'socket' => '/tmp/fcgi-zine.socket',  
'check-local' => 'disable'  

4. Restart your lighttpd!